The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.
† Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Via L. Mancinelli 7, I-20131 Milano, Italy
‡ VTT-Technical Research Centre of Finland, Biologinkuja 7, 02150 Espoo, Finland
§ Department of Chemistry and Bioengineering, Tampere University of Technology, Korkeakoulunkatu 8, FI-33101 Tampere, Finland
Chem. Rev., 2016, 116 (4), pp 2478–2601
Publication Date (Web): January 26, 2016